ATP-dependent reorganization of human sperm nuclear chromatin.

Etiology and Evaluation of Sperm Chromatin Anomalies

Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomes and infertile men possess substantially amount of sperm with chromatin anomalies than fertile men. Routine semen analysis evaluates parameters such as sperm motility and morphology, but does not examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclear chromatin struc...

P-72: Effect of Subinguinal Varicocelectomy on Human Sperm DNA Integrity and Semen Parameters

Background: Varicocele occurs in approximately 15% to 20% of the male population and it is the most common cause of poor semen parameters. It has been demonstrated that patients with varicocele have poor chromatin packing, DNA damage and nuclear anomalies than the healthy men. Therefore, the aim of this study was to evaluate sperm chromatin integrity and semen parameters in these patients after...

Memoirs of an insult: sperm as a possible source of transgenerational epimutations and genetic instability.

Male transgenerational epigenetic effects have been discovered in the discipline of mouse radiation genetics, using genetic and non-genetic readouts. The mechanism to explain the origin of the transmission of epigenetic and genetic instability is still unknown. In a search for a hypothesis that could satisfy the data, we propose that regulation of chromosome structure in the germline, by the oc...

The Effect of Cigarette Smoking on Human Sperm Creatine Kinase Activity: As An ATP Buffering System in Sperm

O-4: Protective Effect of Silymarin on Sperm Viability and Chromatin Packing in Varicocele-Induced Rats

Background: Varicocele has been repeatedly implicated as a cause of infertility in selected men. Previous studies have showed high levels of seminal oxidative stress, as evidenced by increased levels of ROS and reduced total antioxidant capacity in varicocele men, suggesting that sperm dysfunction in varicocele patients may be partly related to oxidative stress. Thus current study was designed ...